Josephine O Ofeimun1
,
Ifeanyi E Usifo1,
Enitome E Bafor2,
Fabian C Ameachina2
For correspondence:- Josephine Ofeimun Email: jofeimun@uniben.edu Tel: +2348064942568
Published: 28 December 2018
Citation: Ofeimun JO, Usifo IE, Bafor EE, Ameachina FC. Toxicity and phytochemical studies on the root of Icacina tricantha (Icacinaceae). J Sci Pract Pharm 2018; 5(1):209-210 doi: 10.47227/jsppharm.v5i1.09
© 2018 The author(s).
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Purpose: To investigate the acute and sub-acute toxicity of the methanol extract of the root tuber of Icacina tricantha. Methods: The toxicity of the methanol extract of the root tuber of I. icacina was investigated by administering a single dose of 1.0 g/kg on male and female albino mice and observing and evaluating them for parameters of toxicity after 24 hours and 14 days. Results: At 24 hours there were no visible signs of toxicity, and no death occurred. However, there was a significant (p < 0.05) decrease in temperature of the treated group after 24 hours compared to control. There was also a slight increase in body weight of male animals compared to the female animals, while no changes were observed with respect to organ weight and histological parameters after same time. There was equally a significant decrease (p<0.001) in the lymphocytes and mean corpuscular volume of treated animals compared to control, which did not present after 14 days. No death or visible signs of toxicity was observed after 14 days. Conclusion: The findings of this study suggest that the extract of I. icacina may be safe at this dose.
